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Change in vincristine accumulation caused by AbA in tumor cells with multidrug resistance
| Drug | Intracellular concn (pmol/106 cells) (% changea in concn of [3H]vincristine at the following different doses [μg/ml] of AbA or verapamil):
|
|||
|---|---|---|---|---|
| 0 | 0.1 | 1 | 10 | |
| AbA | 0.052 (100) | 0.042 (82) | 0.077 (149) | 0.247 (478) |
| Verapamil | 0.060 (116) | 0.162 (312) | 0.366 (708) | |
The change in concentration is given as a percentage of the concentration without AbA or verapamil.
