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. 2023 Sep 25;19(9):e1010973. doi: 10.1371/journal.pgen.1010973

Fig 1. Effect on lifespan of post-developmental TDP-43 overexpression in individual glial cell types of the Drosophila CNS.

Fig 1

(A) To induce post development expression of hTDP-43 and 5XUAS-Unc84-2XGFP, flies were reared at 21°C and shifted to 29°C upon eclosion (day 0). (B-F) Lifespan analyses with expression in each individual glial cell type, compared to a control without TDP-43; Effects were significant (Log-Rank) for each glial cell type (PNG, P< 9.003e-28; SPG, P< 1.596e-7; ALG, P< 9.198e-24; CG, P< 0.00000197; EG, P< 0.000004475). (G) Lifespan analysis for pan-glial TDP-43 expression compared to a control without TDP-43 (Repo) P<2.231e-27. Gal4 lines and full genotypes used for each cell type are listed in methods.