TABLE 3.
Bacterial counts in the lungs at 96 h postinfection with S. pneumoniae N1387a
| Treatment group (dose [mg/kg]) (n = 5) | Log10 CFU/pair of lungs (mean ± SD) |
|---|---|
| Untreated control | No survivors |
| Clavulanate (50) | 7.9 ± 0.5 |
| Amoxicillin (100) | 7.0 ± 0.5 |
| Amoxicillin-clavulanate (100/50) | 4.1 ± 2.3b |
| Amoxicillin (200) | 4.0 ± 2.9 |
| Amoxicillin-clavulanate (200/50) | 2.0 ± 1.0 |
| Amoxicillin (350) | 4.5 ± 1.8 |
| Amoxicillin-clavulanate (350/50) | 2.3 ± 1.4 |
a
The compounds were administered b.i.d.
b
P < 0.05 versus the results for treatment with amoxicillin alone.