TABLE 4.
Values of population pharmacokinetic parameters for amikacin estimated for 57 febrile, severely neutropenic patients
| Parameter | Population mean
|
% Interindividual variability
|
||
|---|---|---|---|---|
| Estimate | SE | Estimatea | SEb | |
| θ1c | 0.797 | 0.181 | ||
| θ2c | 0.640 | 0.162 | ||
| θ3c (y/100) | 0.985 | 0.106 | ||
| θ4c (liter/h) | 1.66 | 0.34 | ||
| CL (liter/h) | 21 | 8 | ||
| V1 (liter) | 8.92 | 1.17 | 15 | 6 |
| CLD (liter/h) | 4.43 | 0.76 | 30 | 6 |
| Vt (liter) | 11.4 | 1.3 | 25 | 7 |
| θ8d | 0.939 | 0.060 | ||
| ςɛ2e | 0.189 | 0.083 | ||
a
Estimate of variability expressed as a coefficient of variation.
b
Standard error (SE) of the coefficient of variation, taken as [SE (var)/var] × 
.
c
Parameters expressing clearance as a function of covariates (see text).
d
Exponent b of the residual-error model (see text).
e
Variance of the residual-error model (see text).