TABLE 5.
Derived values of population pharmacokinetic parameters for amikacin in neutropenic patientsa
| Value | CL (liters/h)
|
t1/2β (h)
|
VSS (liter) | ||
|---|---|---|---|---|---|
| Men | Women | Men | Women | ||
| Mean | 3.82 | 3.40 | 5.6 | 6.0 | 20.6 |
| SD | 1.52 | 1.28 | 2.0 | 2.2 | 3.4 |
| Median | 3.60 | 3.25 | 5.2 | 5.6 | 20.1 |
| 5 and 95b | 2.0 and 6.5 | 1.8 and 5.7 | 2.9 and 9.2 | 3.2 and 10.0 | 15.8 and 26.4 |
a
Based on data for 1,000 simulated individuals with the following covariate distributions: age = 51 ± 16 (N); body weight = 67 ± 13 kg (N); SCR = 85 ± 37 μmol (LN).
b
5 and 95, 5th and 95th percentiles of the distribution, respectively.