TABLE 6.

Studies of the pharmacokinetics of amikacin given at a dosage of 7.5 mg/kg b.i.d. to neutropenic patients and healthy volunteers

Reference	No. of subjects	CLCR (ml/min)	Subject characteristic	Sampling designa	Modelb	CL (liters/h)	VSS (liter/kg)	t1/2β (h)
14	8	105 ± 11	Nonfebrile	10 samples (0–8 h)	Two	9.2	0.45	2.1
17	10	108 ± 38	Febrile	P, T	One	7.6	0.40	2.9
11	28	86 ± 30	Febrile	P, T	One	5.7	0.38	3.8
40	27	103 ± 28	Febrile	P and T at steady state	One	7.2	0.40	2.3
14	8	106 ± 5	Healthy volunteers	10 samples (0–8 h)	Two	6.7	0.34	2.3
13	6	<125c	Healthy volunteers	11 samples (0–24 h)	Two	7.6	0.30	1.9

^aP, peak; T, trough. 

^bOne and two, one-compartment model and two-compartment model, respectively. 

^cThe value is the S_CR (in micromolar).