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. 2023 Aug 4;52(3):86. doi: 10.3892/ijmm.2023.5289

Figure 1.

Figure 1

Schematic of the modification mechanism of m6A methylation. 'Writers' (yellow, green or aqua rectangles) catalyze methylation by adding the methyl group (red oval) to the adenine base. 'Erasers' (pink rectangles) remove the methyl group (red oval) from the methylation sites. 'Readers' (purple rectangles) recognize these signals and regulate downstream protein functions. The METTL3/METTL14 'writer' complex recognizes RNA substrate and exerts a catalytic effect. METTL, methyltransferase-like; MTD3, methyltransferase domain; SAM, S-adenosylmethionine methionine; WTAP, Wilms tumor 1-associated protein; RBM, RNA-binding motif protein; VIRMA, Vir-Like m6A methyltransferase-associated; FTO, fat mass and obesity-associated; ALKBH5, AlkB homolog 5; HNRNP, heterogenous nuclear ribonucleoproteins; YTHD, YTH domain-containing/family proteins; IGF2BP, insulin-like growth factor-2 mRNA-binding proteins; EIF3, eukaryotic initiation factor 3.