TABLE 3.
PK/PD parameters of trovafloxacin in the sera and lungs of immunocompetent control mice and mice infected with penicillin-susceptible strain P-4241 following s.c. administration of a single dose of 25 mg/kga
| Mouse group and sample | Cmax (μg/ml or g) | C24h (μg/ml or g) | Tmax (h) | t1/2 (h) | AUC0–24 (μg · h/ml or g) | Lung/serum AUC ratio | AUC/MIC ratio |
|---|---|---|---|---|---|---|---|
| Uninfected control | |||||||
| Serum | 3.8 | 0.01 | 0.22 | 2.8 | 16.6 | 277 | |
| Lung tissue | 20.4 | 0.43 | 0.24 | 4.2 | 131 | 7.9 | 2,183 |
| Infected | |||||||
| Serum | 4.4 | 0.51 | 0.66 | 7.5 | 49.5 | 825 | |
| Lung tissue | 19.9 | 3.7 | 0.40 | 9.7 | 287 | 5.8 | 4,783 |
a
Values are calculated data for 2 × 3 pooled serum and lung samples taken at 0.25, 0.5, 1, 2, 4, 6, 8, 12, and 24 h postdosing. The trovafloxacin MIC and MBC for the challenge strain are 0.06 and 0.25 μg/ml, respectively.