TABLE 4.

PK/PD parameters of trovafloxacin in the sera and lungs of leukopenic control mice and mice infected with penicillin-resistant strain P-54988 following s.c. administration of a single dose of 25 mg/kg^a

Mouse group and sample	Cmax (μg/ml or g)	C24h (μg/ml or g)	Tmax (h)	t1/2 (h)	AUC0–24 (μg · h/ml or g)	Lung/serum AUC ratio	AUC/MIC ratio
Uninfected control
Serum	3.7	0.1	0.70	4.8	29		232
Lung tissue	3.6	0.2	0.97	5.3	33	1.1	264
Infected
Serum	2.9	0.3	0.53	7.4	33		264
Lung tissue	2.7	0.3	0.86	6.7	29	0.9	232

^aValues are calculated data for 2 × 3 pooled serum and lung samples taken 0.25, 0.5, 1, 2, 4, 6, 8, 12, and 24 h postdosing. The trovafloxacin MIC and MBC for the challenge strain are 0.125 and 0.25 μg/ml, respectively.