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Schematic overview of the SpaRx method. (A) Concept design of the SpaRx model. With the pharmacogenomic profiles serving as the source data, SpaRx enables to predict the cells’ response to drugs in SCST data via graph-based adversarial adaptation. (B) SpaRx comprises three components (feature extractors, drug-response predictor and discriminators) to leverage source domain and predict cellular response in target domain.
