Table 2.
Cox proportional hazard results for red blood cell distribution width (RDW), C-reactive protein (CRP) and 25 hydroxyvitamin D [25(OH)D] associations with all-cause mortality, adjusted for sex, age, ethnicity, body mass index (BMI), smoking pack-years, drinking and deprivation index
| Model | All-cause mortality hazard ratio per 1% increase in the RDW (95% CI) N = 324 467 | All-cause mortality hazard ratio per 1-mg/L increase in CRP (95% CI) N = 317 917 | All-cause mortality hazard ratio per 1-nmol/L increase in 25(OH)D (95% CI) N = 303 858 |
|---|---|---|---|
| (i) Uncorrected Cox proportional hazard | 1.203 (1.194, 1.212) | 1.029 (1.028, 1.031) | 0.993 (0.992, 0.994) |
| (ii) Corrected for regression dilution in main exposure using intraclass correlation coefficient | 1.430 (1.407, 1.453) | 1.107 (1.099, 1.116) | 0.988 (0.986, 0.989) |
| (iii) Corrected for regression dilution in main exposure using regression calibration | 1.482 (1.398, 1.567)a | 1.119 (1.095, 1.143)a | 0.988 (0.987, 0.990)a |
| (iv) Corrected for regression dilution in main exposure and both BMI and smoking pack-years (confounders) using regression calibration | 1.480 (1.394, 1.565)a | 1.118 (1.095, 1.142)a | 0.989 (0.987, 0.990)a |
a
Bootstrapped 95% CIs with 10 000 replications.