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. 2023 Oct 2;20(10):1530–1536. doi: 10.1038/s41592-023-02007-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Volcano plot after ANOVA across 20 spatially guided bins. Color overlay specifies adjusted p value, the top 40 significant proteins are labeled. b, Score and multiple testing-adjusted p value of a Shapiro-Wilk normality test. Lowest proteins are labeled. c, Relative expression normalized to 1 for each contributing protein (n = 10) of the least significant Shapiro-Wilk hits in b, from portal to central distance-guided bins.