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. 2023 Oct 2;20(10):1530–1536. doi: 10.1038/s41592-023-02007-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Unique proteins quantified in our scDVP workflow with mDIA ranked by signal intensity (two single-shape and a reference proteome channels, 31 min Evosep gradient, 15 cm column at 100 nl min⁻¹, dia-PASEF with optimized window design, library-dependent search in DIA-NN). Names of highest- and lowest-ranking proteins, as well as transcription factors, are indicated. b, Left: intensity of the top four histone proteins across all samples, including hepatocytes and quality control arteriole structures. Colors are specific for the indicated histone subunit. Right: WGA stain of cells corresponding to marked data points in the scatter plot. The color scale is signal intensity. Scale bar, 10 μm. Data from three mice were pooled.