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. 2023 Oct 5;220(12):e20231242. doi: 10.1084/jem.20231242

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© 2023 Chan et al.

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Figure 3. — Mapping of signaling events induced by CD3 versus CD28 receptor engagement. (A and B) Population response curves (mean ± s.d.) versus single-cell AUC/AUP distributions (violin plots with median and quartiles) comparing the indicated αCD3 versus αCD28 antibody stimulation or (B) CRISPR-induced CD3-KO versus CD28-KO condition following αCD3/αCD28 antibody stimulation added at the indicated time point. Radar plots represent normalized mean values of corresponding single-cell AUC/AUP distributions. ns: P value ≥0.05, *P value between 0.01 and 0.05, **P value between 0.001 and 0.01, ***P value between 0.0001 and 0.001, ****P value <0.0001, two-tailed unpaired t test. Results are representative of three independent experiments in A or two independent experiments in B.