TABLE 1.

Summary of levofloxacin pharmacokinetic parameter estimates for 10 healthy subjects^a

Levofloxacin dose and day	Cmax (μg/ml)	Tmax (h)	AUCb (μg · h/ml)	CL/F		Vss/F		t1/2 (h)	Cumaxc (μg/ml)	Aed (% dose)	CLR
				ml/min	ml/min/kg	Liters	Liters/kg				ml/min	ml/min/kg
750 mg
Day 1 (single dose)	7.13 ± 1.44	1.9 ± 0.7	82 ± 14	157 ± 28	2.06 ± 0.42	90 ± 14	1.17 ± 0.10	7.7 ± 1.3	403 ± 249	75 ± 6	118 ± 28	1.55 ± 0.36
Day 10 (steady state)	8.60 ± 1.86	1.4 ± 0.5	91 ± 18	143 ± 29	1.88 ± 0.43	100 ± 16	1.29 ± 0.13	8.8 ± 1.5	822 ± 437	79 ± 5	116 ± 28	1.52 ± 0.39
1 g
Day 14 (single dose)	8.85 ± 1.86	1.7 ± 0.4	111 ± 21	156 ± 34	2.05 ± 0.49	96 ± 22	1.24 ± 0.15	7.9 ± 1.5	667 ± 286	73 ± 8	113 ± 2.6	1.48 ± 0.36
Day 23 (steady state)	11.8 ± 2.52	1.7 ± 0.6	118 ± 19	146 ± 29	1.91 ± 0.40	105 ± 27	1.36 ± 0.17	8.9 ± 2.5	992 ± 377	71 ± 5	106 ± 23	1.38 ± 0.31

^aValues are means ± SD. 

^bThe AUC is the AUC_0–∞ for single doses (days 1 and 14) and the AUC_0–24 at steady state (days 10 and 23). 

^cCu_max, peak urinary levofloxacin concentration. 

^dAe, cumulative amount of levofloxacin recovered from urine from 0 to 72 h for single doses (days 1 and 14) and from 0 to 24 h at steady state (days 10 and 23).