TABLE 2.
Ratios of the levofloxacin pharmacokinetic parameter estimates (1-g dose versus 750-mg dose)
| Dose condition | Ratio of indicated parameter value for 1-g dose to value for 750-mg dosea
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cmax | Tmax | AUC | CL/F | Vss/F | t1/2 | Cumax | Ae | CLR | |
| Single dose | 1.25 ± 0.21 | 0.95 ± 0.40 | 1.35 ± 0.14 | 0.99 ± 0.10 | 1.06 ± 0.11 | 1.02 ± 0.06 | 2.02 ± 1.12 | 0.98 ± 0.12 | 0.97 ± 0.15 |
| Steady state | 1.40 ± 0.27 | 1.28 ± 0.47 | 1.31 ± 0.16 | 1.03 ± 0.12 | 1.05 ± 0.19 | 1.00 ± 0.16 | 1.5 ± 0.96 | 0.91 ± 0.06 | 0.92 ± 0.09 |
a
For definitions of AUC, Cumax, and Ae, see the footnotes to Table 1. Values are means ± SD.