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. 2023 Oct 5;13:16743. doi: 10.1038/s41598-023-42331-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ANGPT2, BMP10, and FGF23 outperform NTproBNP. A comparison of model performance (using discovery cohort data) by area under the AUC and corresponding 95% CI demonstrating that (1) NTproBNP alone provides minimal improvements to the AUC in this cohort with known heart failure status, and (2) the incremental addition of biomarkers BMP10, ANGPT2, and FGF23 substantially improves the AUC. AUC area under the ROC curve, CI confidence intervals, ANGPT2 angiopoietin 2, BMP10 bone morphogenetic protein 10, FGF23 fibroblast growth factor 23.