Figure 4.

MSC treatment inhibited the infiltration of inflammatory monocytes

(A) Subclustering of myeloid cells from sham-, IRI-AKI-, and MSC-treated kidneys. (B) Expression of the top 8 DEGs in the 9 myeloid cell subclusters. (C) Relative contribution of each myeloid cell type in the sham-, IRI-AKI-, and MSC-treated groups. (D) Flow cytometric analysis of Ly6c2+CD11b+ monocyte frequencies in the IRI-1 d and sham groups. (E) Flow cytometric analysis of CD11b+F/480+ macrophages frequencies in the IRI-3 d and MSC therapy groups. (F) Heatmap showing intercellular crosstalk between myeloid cells and TECs (ligand-receptor interaction pairs). (G) Circos plots showing the myeloid-TEC immune interaction networks.