TABLE 3.
Antibiotic activity against an isogenic pair of S. epidermidis strainsa
| Strain | Drug | MIC (μg/ml) for bacteria suspended in TSB-S | MBC (μg/ml)
|
|||
|---|---|---|---|---|---|---|
| TSB-S
|
PBS-GCP
|
|||||
| Suspended bacteria | Adherent bacteria | Suspended bacteria | Adherent bacteria | |||
| S. epidermidis RP62A | Amikacin | 16a | 64 | >256 | >256 | >256 |
| Levofloxacin | 0.125 | 0.5 | 0.5 | 0.5 | 1 | |
| Rifampin | <0.008 | <0.008 | >2 | 0.016 | 2 | |
| Teicoplanin | 2 | 4 | 64 | 4 | >128 | |
| S. epidermidis M7 | Amikacin | 16 | 64 | >256 | >256 | 256 |
| Levofloxacin | 0.125 | 0.25 | 1 | 0.5 | 1 | |
| Rifampin | <0.008 | 0.008 | >2 | <0.008 | 2 | |
| Teicoplanin | 4 | 4 | 64 | 4 | >128 | |
a
The MICs and MBCs for suspended and adherent bacteria were measured in supplemented TSB (TSB-S) and a special slow growth medium (PBS-GCP).