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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Apr 6;42(4):112335. doi: 10.1016/j.celrep.2023.112335

Figure 3. Female GLUT3cKO mice have smaller CA1 and total brain volumes, and decreased HP [1-13C]lactate-to-pyruvate ratios.

Figure 3.

(A) Representative in vivo T2-weighted images of 10- to 14-month-old mice used for volumetric analyses. The hippocampal volume was significantly smaller in female GLUT3cKO mice. Data are means ± SEM; n = 6–7 mice/group.

(B) Total brain and thalamus volumes calculated from in vivo T2-weighted images of 10- to 14-month-old mice were smaller in female GLUT3cKO mice, while ventricle volume was unchanged. n = 6–7 mice/group.

(C) Representative ex vivo T2-weighted images of 19-month-old mice used for volumetric analyses. CA1, hippocampal, and entire brain volumes were smaller in female GLUT3cKO mice. n = 3 mice/group.

(D and E) [18F]FDG-PET signal from the hippocampus (D) and specifically from the CA1 area (E) was similar between 12- and 14-month-old females and males. n = 6 mice/group.

(F) Representative 13C spectra of 8- to 14-month-old mice showing HP [1-13C]pyruvate and HP [1-13C]lactate levels from a region containing CA1 (red square) for female and male mice. HP [1-13C]lactate-to-pyruvate ratios were significantly lower in female GLUT3cKO mice. n = 6–7 mice/group.

*p % 0.05,**p % 0.01,***p % 0.001 by unpaired t tests.