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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Apr 6;42(4):112335. doi: 10.1016/j.celrep.2023.112335

Figure 5. Female PKM1cKO mice have increased metabolic conversion of HP pyruvate to lactate.

Figure 5.

(A) Representative in vivo T2-weighted images of 11- to 15-month-old mice used for volumetric analyses showed no differences between female or male PKM1cKO and PKM1WT mice for the entire brain, hippocampus, thalamus, or ventricles. Data are means ± SEM. n = 9 PKM1WT, 14 KO females, and n = 7 PKM1WT, 13 KO males.

(B and C) There were no differences in [18F]FDG-PET signal between 11- and 14-month-old mice PKM1WT and PKM1cKO mice in the hippocampus (B) or CA1 (C). n = 5–6 mice/group.

(D) Representative 13C spectra of 11- to 15-month-old mice showing HP [1-13C]pyruvate and HP [1-13C]lactate levels from a region containing CA1 (red square). HP [1-13C]lactate-to-pyruvate ratios were markedly higher in female PKM1cKO versus PKM1WT mice, but were similar in males. n=9 PKM1WT, 14 KO females and seven PKM1WT, 13 KO males. **p%0.01 by unpaired t tests.