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Algorithm to determine the IRS and respective INSM1 expression groups
| Immunoreactive score (IRS) | ||
|---|---|---|
| Score | Staining intensity | Percentage of positive cells |
| 0 | No staining reaction | 0 |
| 1 | Weak staining reaction | <10 |
| 2 | Moderate staining reaction | 10–50 |
| 3 | Strong staining reaction | 51–80 |
| 4 | >80 | |
| IRS = score (staining intensity) × score (percentage of positive cells) | ||
| INSM1 expression groups | ||
| IRS 0–1 | INSM1 negative | |
| IRS 2–3 | INSM1 low | |
| IRS 4–8 | INSM1 moderate | |
| IRS 9–12 | INSM1 high | |
