Table 2.
Distribution and survival associations of clinicopathological characteristics of the main cohort
| Overall n (%) | Mean OS (SE) [months] | p value | Mean DSS (SE) [months] | p value | Mean DFS (SE) [months] | p value | |
|---|---|---|---|---|---|---|---|
| Age | <0.001 | 0.02 | 0.945 | ||||
| Below median | 511 (48.5%) | 86.10 (2.2) | 90.88 (2.1) | 82.03 (2.3) | |||
| Median and above | 543 (51.5%) | 71.61 (2.2) | 83.63 (2.3) | 82.13 (2.4) | |||
| Sex | 0.26 | 0.94 | 0.69 | ||||
| Male | 608 (57.7%) | 77.52 (2.1) | 87.33 (2.1) | 82.83 (2.2) | |||
| Female | 446 (42.3%) | 80.64 (2.4) | 87.24 (2.4) | 80.96 (2.6) | |||
| pT | <0.001 | <0.001 | <0.001 | ||||
| 1 | 80 (7.6%) | 96.57 (4.9) | 114.12 (3.2) | 108.49 (3.8) | |||
| 2 | 188 (17.8%) | 92.35 (3.2) | 103.32 (2.8) | 99.37 (3.2) | |||
| 3 | 588 (55.8%) | 79.44 (2.1) | 88.03 (2.1) | 81.83 (2.2) | |||
| 4 | 198 (18.8%) | 56.92 (3.7) | 60.15 (3.8) | 54.83 (4.0) | |||
| pN | <0.001 | <0.001 | <0.001 | ||||
| 0 | 581 (55.1%) | 89.00 (1.9) | 101.20 (1.7) | 99.08 (1.8) | |||
| 1 | 296 (28.1%) | 75.01 (3.0) | 80.23 (3.0) | 72.49 (3.2) | |||
| 2 | 177 (16.8%) | 51.65 (3.9) | 54.73 (4.1) | 43.21 (4.0) | |||
| pM | <0.001 | <0.001 | <0.001 | ||||
| 0 | 897 (85.1%) | 86.21 (1.6) | 95.98 (1.5) | 90.77 (1.7) | |||
| 1 | 157 (14.9%) | 39.60 (3.4) | 42.15 (3.7) | 33.72 (3.6) | |||
| UICC stage | <0.001 | <0.001 | <0.001 | ||||
| 1 | 213 (20.2%) | 96.64 (2.9) | 111.11 (2.1) | 107.84 (2.4) | |||
| 2 | 351 (33.3%) | 86.01 (2.6) | 97.00 (2.4) | 95.76 (2.6) | |||
| 3 | 327 (31.0%) | 80.60 (2.8) | 86.44 (2.8) | 76.13 (3.0) | |||
| 4 | 163 (15.5%) | 38.80 (3.3) | 41.27 (3.6) | 32.69 (3.4) | |||
| WHO grade | <0.001 | <0.001 | <0.001 | ||||
| Low grade | 708 (67.2%) | 86.00 (1.8) | 95.24 (1.7) | 89.62 (1.9) | |||
| High grade | 346 (32.8%) | 64.74 (2.8) | 71.72 (2.9) | 66.83 (3.0) | |||
| Resection margin | <0.001 | <0.001 | <0.001 | ||||
| R0 | 974 (92.4%) | 82.53 (1.6) | 91.81 (1.5) | 86.78 (1.7) | |||
| R1 | 50 (4.7%) | 41.00 (7.2) | 42.53 (7.5) | 29.47 (6.1) | |||
| R2 | 30 (2.8%) | 24.99 (4.5) | 25.00 (4.5) | 21.52 (3.7) | |||
| Tumor localization | 0.14 | 0.34 | 0.16 | ||||
| Cecum | 150 (14.2%) | 78.24 (4.1) | 88.30 (4.1) | 87.20 (4.2) | |||
| Ascending colon | 276 (26.1%) | 77.62 (3.2) | 86.24 (3.2) | 78.61 (3.4) | |||
| Transverse colon | 83 (7.9%) | 70.26 (6.0) | 83.40 (5.9) | 83.82 (6.1) | |||
| Descending colon | 94 (8.9%) | 74.69 (5.1) | 81.15 (5.1) | 77.02 (5.5) | |||
| Sigmoid colon | 332 (31.4%) | 84.60 (2.7) | 91.67 (2.6) | 86.41 (2.9) | |||
| Rectum | 119 (11.3%) | 75.80 (4.6) | 83.88 (5.9) | 74.48 (5.1) | |||
| Tumor histology | <0.001 | <0.001 | <0.001 | ||||
| Conventional adenocarcinoma | 1,033 (98.0%) | 79.44 (1.6) | 88.05 (1.6) | 82.81 (1.7) | |||
| MANEC/NEC | 21 (2.0%) | 26.51 (6.2) | 26.51 (6.2) | 22.99 (6.1) | |||
| MSI status | 0.014 | <0.001 | <0.001 | ||||
| Microsatellite stable | 889 (84.3%) | 77.21 (1.7) | 85.04 (1.7) | 79.46 (1.8) | |||
| Microsatellite unstable | 165 (15.7%) | 88.36 (3.8) | 100.88 (3.4) | 97.29 (3.7) |