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. 2023 Sep 26;9(10):e20428. doi: 10.1016/j.heliyon.2023.e20428

Table 4.

Chalcone derivatives investigated against HRV.

Compound(s) “Chemical name(s)” Virus subtype Study model(s) Results Inhibition mechanism Refs.
Chalcone amides including: Ro 09–0535 “4-ethoxy-2-hydroxy-6-methoxy-N-[(4-methoxyphenyl)methyl]benzamide”
Ro 09–0696 “2-hydroxy-6-methoxy-N-[(4-methoxyphenyl)methyl]-4-(3-methylbut-2-enoxy)benzamide”
Ro 09–0881 “4-ethoxy-2-hydroxy-6-methoxy-N-[[4-(methylamino)phenyl]methyl]benzamide”		 HRV-2, In vitro IC50: 0.0040, 0.0014, and 0.052 μg/mL, respectively Inhibition of the uncoating of rhinovirus by keeping the viral capsid protein stable [96]
Ro 09–0410 “(E)-1-(4-ethoxy-2-hydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one” HRV9 In vitro IC50: 0.03 μg/mL, Inactivation of the capsid protein by binding to a specific site in the rhinovirus capsid [92]

HRV: Human rhinovirus, IC50: Half maximal inhibitory concentration.