Table 6.

Chalcone derivatives investigated against dengue virus.

Compound(s) “Chemical name(s)”	Virus subtype	Study model(s)	Assay results	Inhibition mechanism	Refs.
Cardamonin “(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one”	DEN-2	In vitro	Ki: 377 μM	Non-competitive inhibition of NS2B/NS3 protease	[112]
4-Hydroxypanduratin A “[(1R,2S,6R)-3-methyl-2-(3-methylbut-2-enyl)-6-phenylcyclohex-3-en-1-yl]-(2,4,6-trihydroxyphenyl)methanone”	DEN-2	In vitro	Ki: 21 μM	Competitive inhibition of NS3 protease	[112]
Panduratin A “(2,6-dihydroxy-4-methoxyphenyl)-[(1R,2S,6R)-3-methyl-2-(3-methylbut-2-enyl)-6-phenylcyclohex-3-en-1-yl]methanone”	DEN-2	In vitro	Ki: 25 μM	Competitive inhibition of NS3 protease	[112]

Dengue virus (DENV), K_i: inhibitory constant.