Table 5.
Comparison of adverse events in treatment cohort.
| Grade | WBRT+SIB(n=42) | SRS(n=48) | ||
|---|---|---|---|---|
| Acute radiation injury | Nausea/vomiting | 0 | 19 | 27 |
| 1 | 14 | 11 | ||
| 2 | 7 | 9 | ||
| 3 | 2 | 1 | ||
| 4 | 0 | 0 | ||
| Leukopenia | 0 | 27 | 32 | |
| 1 | 10 | 7 | ||
| 2 | 5 | 8 | ||
| 3 | 0 | 1 | ||
| 4 | 0 | 0 | ||
| Thrombocytopenia | 0 | 34 | 39 | |
| 1 | 7 | 7 | ||
| 2 | 1 | 2 | ||
| 3 | 0 | 0 | ||
| 4 | 0 | 0 | ||
| CNS symptoms | 0 | 33 | 37 | |
| 1 | 6 | 7 | ||
| 2 | 2 | 4 | ||
| 3 | 1 | 0 | ||
| 4 | 0 | 0 | ||
| Late radiation injury | CNS symptoms | 0 | 22 | 35 |
| 1 | 12 | 10 | ||
| 2 | 5 | 2 | ||
| 3 | 2 | 1 | ||
| 4 | 1 | 0 | ||
| 5 | 0 | 0 |
WBRT+SIB, Whole- Brain Radiation Therapy with Simultaneous Integrated Boost; SRS, Stereotactic Radiosurgery; CNS, central nervous system.