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. 2023 Sep 22;17:1226479. doi: 10.3389/fnins.2023.1226479

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Copyright © 2023 Cubillos Arcila, Dariva Machado, Martins, Leotti, Schüle, Peyré-Tartaruga and Saute.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Progression of ClinROs and PerFOs modeled by disease duration in the overall HSP group. (A–H) indicate the results for the different clinical outcome assessments. SPRS, Spastic Paraplegia Rating Scale; mSPRS, Motor Spastic Paraplegia Rating Scale; 10MWT-SSWS, 10-meter walking test at self-selected speed; 10MWT-MWS (s), 10-meter walking test at maximal speeds; TUG-SSWS, Timed-Up and Go at self-selected walking speed; TUG-MWS, Timed-Up and Go test at maximal walking speed; LRI, locomotor rehabilitation index (%); 6MWT, 6-min walking test.