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. 2023 Sep 22;17:1226479. doi: 10.3389/fnins.2023.1226479

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Copyright © 2023 Cubillos Arcila, Dariva Machado, Martins, Leotti, Schüle, Peyré-Tartaruga and Saute.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Annual progression of clinical outcome assessments in the overall HSP group. (A–H) indicate the results for the different clinical outcome assessments. Variables that did not have a normal distribution were log-transformed, except for 10MWT-MWS which was Box-Cox transformed, for the analyses and back-transformed to raw values. SPRS, Spastic Paraplegia Rating Scale; mSPRS, Motor Spastic Paraplegia Rating Scale; 10MWT-SSWS, 10-meter walking test at self-selected speed; 10MWT-MWS (s), 10-meter walking test at maximal speeds; TUG-SSWS, Timed-Up and Go at self-selected walking speed; TUG-MWS, Timed-Up and Go test at maximal walking speed; LRI, locomotor rehabilitation index (%); 6MWT, 6-min walking test.