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. 2023 Jun 20;15:220–228. doi: 10.1016/j.xjon.2023.05.013

Figure 5.

Figure 5

Phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) signaling. Immunoblotting showed a significant increase in PI3K expression in the hypoxia-conditioned extracellular vesicle group (HEV, n = 7) compared with saline control (CON, n = 6). There was a trend towards increased phospho-protein kinase B (pAKT) and a significant increase in the pAKT to AKT ratio in the HEV group compared with CON. Graphs represent data points mean with standard deviation. Immunoblotting data are fold change normalized to average control. Data points greater than 2 standard deviations from the mean are excluded from analysis. GAPDH, Glyceraldehyde 3-phosphate dehydrogenase. ∗P < .05, ∗∗P < .01.