Table E2.

Clinical trial secondary outcomes: patient intensive care unit (ICU) secondary outcomes^∗†

Outcome	Red blood cell group		P value
	Fresh	Standard-issue
28 ICU-free days‡
Median (IQR)	24.1 (19.8-26.0)	24.8 (22.0-25.9)	.35
Mean (SD)	20.6 ± 8.4 [n = 89]	23.0 ± 5.0 [n = 88]
28 Mechanical ventilation-free days§
Median (IQR)	27.6 (24.4-27.9)	27.6 (26.1-27.9)	.30
Mean (SD)	24.1 ± 7.7 [n = 88]	25.7 ± 4.6 [n = 87]
Worst daily PELOD-2 score‖
Median (IQR)	5 (3-8)	4 (2-6)	.12
Mean (SD)	5.8 ± 5.3 [n = 89]	4.5 ± 2.7 [n = 88]
Length of hospital stay (d)
Median (IQR)	6.6 (4.7-12.6)	6.7 (4.7-14.6)	.75
Mean (SD)	17.3 ± 25.4	14.2 ± 20.7

ICU, Intensive care unit; PELOD-2, Pediatric logistic organ dysfunction-2 score.

^∗Values in square brackets indicate number of patients analyzed among all participants.

^†We chose to present both means and medians. However, as normality is not verified, non-parametric test are most appropriate.

^‡Calculated by subtracting the actual ICU length of stay in days from 28. If a patient died within 28 days or stayed in ICU for more than 28 days after randomization, 28 ICU-free days were reported as 0.

^§Calculated by subtracting from 28 the number of days spent receiving mechanical ventilation. If the patient died within 28 days or required mechanical ventilation for more than 28 days after randomization, 28 mechanical ventilation-free days were reported as 0.

^‖Defined by Leteurtre and colleagues.¹⁹ The score ranges from 0 to 33; higher scores indicate greater severity of multiple organ dysfunction syndrome. The score can be estimated over the entire stay in the ICU or over 1 days (daily PELOD-2).