TABLE 1.
Pharmacokinetics of clarithromycin and 14-OH-C when administered with water or grapefruit juicea
| Treatment phase | Cmax (μg/ml) | Tmax (min)b | kel (min−1) | AUC0–∞ (μg · min/ml) | CLt/F (ml/min) | t1/2 (min) |
|---|---|---|---|---|---|---|
| Clarithromycin | ||||||
| Water | 2.4 ± 0.8 | 82.2 ± 35.2 | 2.6 ± 0.7 | 1,202.2 ± 552.5 | 523.6 ± 292.4 | 278.8 ± 64.2 |
| Grapefruit | 2.5 ± 0.9 | 148.1 ± 83.0* | 2.6 ± 0.7 | 1,382.1 ± 556.0 | 444.8 ± 261.3 | 289.3 ± 76.2 |
| 14-OH-C | ||||||
| Water | 1.2 ± 0.4 | 83.5 ± 38.0 | 1.9 ± 0.5 | 817.6 ± 259.7 | 667.3 ± 197.7 | 382.9 ± 94.8 |
| Grapefruit | 1.0 ± 0.3 | 172.7 ± 84.7** | 1.7 ± 0.6 | 833.2 ± 199.4 | 629.8 ± 138.8 | 453.2 ± 157.2 |
a
A 500-mg oral dose of clarithromycin was used. Data are means ± standard deviations.
b
* and **, P ≤ 0.05 and 0.005, respectively, compared with control value.