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Coronary endothelial responses of mouse microvessels to endothelium-independent vasodilator SNP. A, Sham control (no CP-H/R) and CP-H/R vessels with or without RBX treatment in response to the endothelium-independent vasodilator SNP (10–9-10–4 M). B, Bar graph shows vasodilatory response to SNP 10–5 M. SNP, Sodium nitroprusside; CP-H/R, Microvessels undergoing hypoxia/reoxygenation; RBX + CP-H/R, microvessels pretreated with RBX before hypoxia and reoxygenation; RBX, ruboxistaurin.
