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. 2023 Jul 6;15:242–251. doi: 10.1016/j.xjon.2023.06.014

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Schematic of SK-channel–mediated vasodilation. A, CP-H/R increases PKC activity, which phosphorylates SK channels. This results in decreased SK-channel calcium sensitivity and reduces SK-channel opening, leading to reduced potassium currents and reduced endothelial hyperpolarization. This diminishes microvascular relaxation. B, RBX inhibits PKC, preventing PKC-mediated inhibition of SK-channel activity, thereby promoting endothelial hyperpolarization and coronary microvascular smooth muscle relaxation. SK channels are cyan on EC membranes. EC, Endothelial cell; CP-H/R, cardioplegic hypoxia–reoxygenation; PKC, protein kinase C; RBX, ruboxistaurin.