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. Author manuscript; available in PMC: 2024 Feb 22.
Published in final edited form as: Sci Transl Med. 2023 Feb 22;15(684):eade1857. doi: 10.1126/scitranslmed.ade1857

Table 1. Baseline characteristics of study population based on BMI category.

BMI, body mass index; HR, hormone receptor; HER2, human epidermal growth factor receptor 2; TNBC, triple-negative breast cancer.

Variables All (n = 69) BMI < 25 (n = 43) BMI ≥ 25 (n = 26) P
BMI, median (range) 23.9 (19.38–44.9) 22.2 (19.38–24.7) 28.8 (25.3–44.9) <0.001
BRCA mutation, n (%)  0.6
BRCA1 40 (58.0%) 26 (60.5%) 14 (53.8%)
BRCA2 29 (42.0%) 17 (39.5%) 12 (46.2%)
Age, median (range) 40 (25–69) 39.0 (25–60) 44.5 (28–69)  0.03
Diabetes, n (%)  0.4
 No 68 (98.6%) 43 (100.0%) 25 (96.2%)
 Yes 1 (1.4%) 0 (0%) 1 (3.8%)
Dyslipidemia, n (%)  0.01
 No 62 (89.9%) 42 (97.7%) 20 (76.9%)
 Yes 7 (10.1%) 1 (2.3%) 6 (23.1%)
Hypertension, n (%) 0.046
 No 61 (88.4%) 41 (95.3%) 20 (76.9%)
 Yes 8 (11.6%) 2 (4.7%) 6 (23.1%)
Menopausal status, n (%)  0.022
 Pre- 46 (66.7%) 33 (76.7%) 13 (50.0%)
 Post- 23 (33.3%) 10 (23.3%) 13 (50.0%)
Race, n (%)  0.1
 Asian 1 (1.4%) 1 (2.3%) 0 (0.0%)
 Black 2 (2.9%) 2 (4.7%) 0 (0.0%)
 Other 2 (2.9%) 0 (0.0%) 2 (7.7%)
 White 56 (81.2%) 33 (76.7%) 23 (88.5%)
 Missing 8 (11.6%) 7 (16.3%) 1 (3.8%)
Invasive tumor present, n (%)  0.7
 No 39 (56.5%) 25 (58.1%) 14 (53.8%)
 Yes 30 (43.5%) 18 (41.9%) 12 (46.2%)
Tumor subtype, n (%)  >0.9
 HR+ 22 (31.9%) 14 (32.6%) 8 (30.8%)
 HER2+ 1 (1.4%) 1 (2.3%) 0 (0.0%)
 TNBC 9 (13.0%) 5 (11.6%) 4 (15.4%)
 N/A 37 (53.6%) 23 (53.5%) 14 (53.8%)