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. 2023 Sep 21;14:1271268. doi: 10.3389/fphar.2023.1271268

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Copyright © 2023 Liu, Cheng, Huang, Xia, Wang and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition curve of tunlametinib on MEK1/MAP2K1 (H) kinase. (A) Chemical structure of tunlametinib. (B) Tunlametinib on MEK1/MAP2K1 (H). Tunlametinib demonstrated a strong inhibition against MEK1/MAP2K (H) kinase with IC₅₀ value of 1.9 nM. (C) In vitro kinase inhibition curves of tunlametinib and MEK162. Compared to MEK 162, tunlametinib showed stronger inhibitory activity, with IC₅₀ value of 12.1 ± 1.5 nM versus 223.7 ± 16.9 nM.