Table 1.
Relationships between Modified Naples prognostic score and clinicopathological characteristics
| Modified Naples prognostic score | |||||
|---|---|---|---|---|---|
| Variables | Total | Group 0 | Group 1 | Group 2 | P* |
| Age(yr) | 65(55–71) | 63 (54–67) | 65(55–71) | 71(64–79) | 0.005 |
| Sex | 0.010 | ||||
| Male | 102(52.0) | 21(36.8) | 61(55.5) | 20(69.0) | |
| Female | 94(48.0) | 36(63.2) | 49(44.5) | 9(31.0) | |
| BMI (mean ± SD) | 22.1 ± 2.8 | 21.9 ± 2.7 | 22.2 ± 2.7 | 22.0 ± 3.2 | 0.768 |
| ASA class | 0.011 | ||||
| 1 | 5(2.5) | 2(3.5) | 3(2.7) | 0(0.0) | |
| 2 | 126(64.3) | 42(73.7) | 68(61.8) | 16(55.2) | |
| 3 | 35(17.9) | 10(17.5) | 19(17.3) | 6(20.7) | |
| 4 | 30(15.3) | 3(5.3) | 20(18.2) | 7(24.1) | |
| 1/2 | 131(66.8) | 44(77.2) | 71(64.5) | 16(55.2) | 0.090 |
| 3/4 | 65(33.2) | 13(22.8) | 39(35.5) | 13(44.8) | |
| Location | 0.214 | ||||
| Right colon | 63(32.1) | 19(33.3) | 38(34.5) | 6(20.7) | |
| Left colon | 78(39.8) | 19(33.3) | 42(38.2) | 17(58.6) | |
| Rectum | 55(28.1) | 19(33.3) | 30(27.3) | 6(20.7) | |
| Size (cm) | 0.047 | ||||
| d<5 | 97(49.5) | 36(63.2) | 49(44.5) | 12(41.4) | |
| d ≥ 5 | 99(50.5) | 21(36.8) | 61(55.5) | 17(58.6) | |
| Differentiation | 0.487 | ||||
| Low | 28(14.3) | 5(8.8) | 18(16.4) | 5(17.2) | |
| Medium | 136(69.4) | 43(75.4) | 74(67.3) | 19(65.5) | |
| High | 32(16.3) | 9(15.8) | 18(16.4) | 5(17.2) | |
| TNM stage | |||||
| I | 5(2.5) | 1(1.8) | 4(3.6) | 0(0.0) | 0.745 |
| II | 85(43.4) | 26(45.6) | 46(41.8) | 13(44.8) | |
| III | 94(48.0) | 27(47.4) | 53(48.2) | 14(48.3) | |
| IV | 12(6.1) | 3(5.3) | 7(6.4) | 2(6.9) | |
| I/II | 90(45.9) | 27(47.4) | 50(44.5) | 13(44.8) | 0.965 |
| III/IV | 106(54.1) | 30(52.6) | 60(55.5) | 16(55.2) | |
| Tumor | |||||
| T1 | 6(3.1) | 0(0.0) | 6(5.5) | 0(0.0) | 0.237 |
| T2 | 23(11.7) | 5(8.8) | 11(10.0) | 7(24.1) | |
| T3 | 89(45.4) | 30(52.6) | 45(40.9) | 14(48.3) | |
| T4 | 78(39.8) | 22(38.6) | 48(43.6) | 8(27.6) | |
| T1/2 | 29(14.8) | 5(8.8) | 17(15.5) | 7(24.1) | 0.158 |
| T3/4 | 167(85.2) | 52(91.2) | 93(84.5) | 22(75.9) | |
| Node | 0.675 | ||||
| N0 | 96(49.0) | 27(47.4) | 55(50.0) | 14(48.3) | |
| N1 | 68(34.7) | 18(31.6) | 40(36.4) | 10(34.5) | |
| N2 | 32(16.3) | 12(21.1) | 15(13.6) | 5(17.2) | |
| N0a | 96(49.0) | 27(47.4) | 55(50.0) | 14(48.3) | 0.946 |
| N1/2 | 100(51.0) | 30(52.6) | 55(50.0) | 15(51.7) | |
| Metastasis | 1.000 | ||||
| M0 | 191(97.4) | 56(98.2) | 107(97.3) | 28(96.6) | |
| M1 | 5(2.6) | 1(1.8) | 3(2.7) | 1(3.4) | |
| Vascular Tumor Thrombus | 0.195 | ||||
| No | 150(76.5) | 39(68.4) | 89(80.9) | 22(75.9) | |
| Yes | 46(23.5) | 18(31.6) | 21(19.1) | 7(24.1) | |
| Nerve Invasion | 0.453 | ||||
| No | 137(69.9) | 40(70.2) | 74(67.3) | 23(79.3) | |
| Yes | 59(30.1) | 17(29.8) | 36(32.7) | 6(20.7) | |
| LNR (%) | 2.6(0.0-14.4) | 3.3(0.0-17.6) | 0.0(0.0-14.2) | 3.1(0.0-12.5) | 0.786 |
| SEMS implantation | 0.068 | ||||
| No | 155(79.1) | 51(89.5) | 83(75.5) | 21(72.4) | |
| Yes | 41(20.9) | 6(10.5) | 27(24.5) | 8(27.6) | |
| Chemotherapy | 0.303 | ||||
| No | 110(56.1) | 28(49.1) | 67(60.9) | 15(51.7) | |
| Yes | 86(43.9) | 29(50.9) | 43(39.1) | 14(48.3) | |
| Radiotherapy | 0.353 | ||||
| No | 190(96.9) | 56(98.2) | 107(97.3) | 27(93.1) | |
| Yes | 6(3.1) | 1(1.8) | 3(2.7) | 2(6.9) | |
| CEA (ng/ml) | 5.7(2.7–16.4) | 5.1(2.4–12.4) | 6.7(2.9–20.6) | 5.5(3.5–17.6) | 0.364 |
| NPS factors | |||||
| ALB (g/L) | 38.1(34.7–40.3) | 39.8(38.3–42.6) | 37.8(34.2–40.3) | 33.6(31.3–35.9) | < 0.001 |
| CHOL (mmol/L) | 4.3(3.6–4.8) | 4.4(4.3–4.8) | 4.3(3.6-5.0) | 3.0(2.6–3.3) | < 0.001 |
| NLR | 3.1(2.0-5.2) | 2.0(1.6–2.5) | 3.6(2.4–5.3) | 6.2(4.3–13.6) | < 0.001 |
| LMR | 2.9(2.0–4.0) | 4.4(3.6-5.0) | 2.6(2.0-3.3) | 1.8(1.3–2.2) | < 0.001 |
ASA class adopted binary classification (1/2 vs. 3/4)
TNM stage adopted binary classification (I/II vs. III/IV).
Tumor stage adopted binary classification (T1/2 vs. T3/4)
Node stage adopted binary classification (N0 vs. N1/2)
Right colon: the proximal two-thirds of the transverse colon, ascending colon and caecum
left colon: the distal third of the transverse colon, splenic flexure, descending colon, sigmoid colon
*P was calculated by the Kruskal–Wallis tests and the analysis of variance (ANOVA) for continuous variables and the Chi-square test and the Spearman’s rank correlation test for categorical variables