Table 2.

Odd ratios and 95% confidence intervals of cancer incidence associated with the mutations

Mutation	No. of cases	No. of controls	Crude OR (95% CI)	Model 1a	Model 2b	Model 3c	Model 4d
mt.1888G > A
Heteroplasmy level	–	–	0.70 (0.16–1.24)	0.69 (0.15–1.23)	0.68 (0.14–1.23)	0.66 (0.11–1.21)	0.67 (0.12–1.22)
Dichotomized
Wild type	280	320	1 (Ref)	1 (Ref)	1 (Ref)	1 (Ref)	1 (Ref)
Mutated	24	39	0.70 (0.17–1.24)	0.69 (0.16–1.23)	0.68 (0.14–1.23)	0.66 (0.12–1.21)	0.67 (0.13–1.22)
mt.16093T > C
Heteroplasmy level	–	–	1.64 (1.06–2.21)	1.63 (1.06–2.21)	1.65 (1.07–2.23)	1.70 (1.12–2.29)	1.68 (1.10–2.27)
Dichotomized
Wild type	272	335	1 (Ref)	1 (Ref)	1 (Ref)	1 (Ref)	1 (Ref)
Mutated	32	24	1.64 (1.09–2.20)	1.63 (1.08–2.19)	1.65 (1.09–2.21)	1.70 (1.13–2.26)	1.67 (1.11–2.24)

^a Adjusted for age, BMI

^b Adjusted for age, BMI, education level, smoking habits, alcohol consumption

^c Adjusted for age, BMI, education level, smoking habits, alcohol consumption, activity at work, activity at home

^d Adjusted for age, BMI, education level, smoking habits, alcohol consumption, activity at work, activity at home, diabetes, hypertension, family history of cancer