Table 2.
Parameters and associated unit costs included in the analysis
| Variables | Arg Pesos | US$ | Source |
|---|---|---|---|
| Analgesics/antipyretics use | |||
| Ibuprofen suspension: 2% suspension 2 g/100ml (Pfizer) | 307.87 | 3.03 | Kairos. Price update 10/04/2021 [47] |
| Ibuprofen suspension: FEBRATIC Ped. 2% (Roemmers) | 294.49 | 2.89 | Kairos. Price update: 09/30/2021 [48] |
| Ibuprofen suspension. PEDIATRIC ACTRON 2% Oral (Bayer) | 302.00 | 2.97 | Kairos. Price update: 10/12/2021 [49] |
| Ibuprofen suspension: Weight average* | 301.45 | 2.96 | |
| Antiemetics use | |||
| Metochlopramide: RELIVERAN for CHILDREN 2 mg/ml. Oral drops x20ml (Gador) | 544.51 | 5.35 | Kairos. Price update: 10/18/2021 [50] |
| Metoclopramide: Vannier 5 mg /ml. Oral Drops x 20ml. (Vannier) | 561.55 | 5.52 | Kairos. Price update: 10/14/2021 [51] |
| Metochlopramide: Gastrocalm 2 mg/ml. Oral Drops x 20ml. (Cassará) | 492.57 | 4.84 | Kairos. Price update: 10/11/2021 [52] |
| Metochlopramide: Oral antiemetic drops x 20ml (weighted average)* | 532.88 | 5.24 | |
| Weighted pediatric outpatient visit | IQVIA Argentina. Unit Costs and Health Events Base [53] | ||
| Pediatric outpatient visit average: public sector (37% of system users) | 609 | 5.99 | [53] |
| Pediatric outpatient visit average: social security as a whole (57% of system users) | 904 | 8.88 | [53] |
| Pediatric outpatient visit average: private sector (6% of system users) | 1.227 | 12.06 | [53] |
| Weighted pediatric outpatient visit (100% of system users) | 814 | 8.00 | [53] |
| Visit to pediatric emergency | IQVIA Argentina. Unit Costs and Health Events Base [53] | ||
| Visit to pediatric emergency average: public sector (37% users of the system) | 1.398 | 13.74 | [53] |
| Pediatric emergency visit average: social security as a whole (57% of system users) | 1.358 | 13.35 | [53] |
| Visit to pediatric emergency average: private sector (6% users of the system) | 1.914 | 18.81 | [53] |
| Visit to pediatric emergency Weighted average (100% of system users)* | 1.406 | 13.82 | [53] |
| Day of hospitalization in pediatric ward | IQVIA Argentina. Unit Costs and Health Events Base [53] | ||
| Day of hospitalization in pediatric ward average: public sector (37% users of the system) | 12,523 | 123.08 | |
| Day of hospitalization in pediatric ward average: social security as a whole (57% users of the system) | 18,649 | 183.28 | [53] |
| Day of hospitalization in pediatric ward average: private sector (6% users of the system) | 54,278 | 533.44 | [53] |
| Day of hospitalization in pediatric ward weighted average (100% users of the system) | 18,520 | 182.02 | [53] |
| Parental costs | |||
| Average cost of 1 bus transfer | 14.3 | 0.14 | Fare and social fare up to 12 km [54] |
| Cost of 1 working day (absenteeism) Average monthly income 26,021 per 24 daily wages | 450 | 4.42 | Employment rate 41.5% [36] |
| Cost of ½ working day (absenteeism) | 225 | 2.21 | Employment rate 41.5% [36] |
| Cost of vaccines | |||
| Price of Pentavalent Vaccine Revolving Fund 2021. Bottle 1 liquid dose | 1.0276 | OPS Revolving Fund [55] | |
| Price of IPV Revolving Fund 2021. Bottle 5 doses | 3.1 | OPS Revolving Fund [55] | |
| Price of Hexavalent Revolving Fund 2021. Bottle 1 dose | 21.12 | OPS Revolving Fund [55] | |
| Cost of Hexavalent vaccine private healthcare sector Hexaxim (Sanofi). Discount rate 40% | 8,817.92 | 86.66 | Kairos. Update date 09/30/2021 [56] |
| Cost of Hexavalent vaccine private healthcare sector Infanrix Hexa (GSK). Discount rate 40% | 8,510.27 | 83.64 | Kairos. Update date 10/14/2021 [57] |
| Cost of Hexavalent vaccine private health sector average. Discount rate 40% | 8,664.09 | 85.15 | |
| Programmatic costs per dose applied. Harvard Analysis (B&MGF) | 3.18 | Portnoy A et al. [37] | |
*weighted average is calculated by the mean
Prices were converted from Argentinean Pesos into US$ using an exchange rate of Arg Pesos 101.75 = US$1 (October 26, 2021) [38]