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. 2023 Oct 6;20:228. doi: 10.1186/s12974-023-02915-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Nisin inhibits the expression of proinflammatory cytokines in the brain following oral polymicrobial infection. To evaluate the immune cytokine profiles in brain tissues, mRNA expression of IL-1β (A), IL-6 (B) and TNF-α (C) were measured by real-time PCR. The amount of mRNA in each reaction was normalized to GAPDH. Data are shown as means ± standard deviation from 6 mice per group. *, the difference between the two groups was significant (P < 0.05). **, the difference between the two groups was significant (P < 0.01). ***, the difference between the two groups was significant (P < 0.001), ns, the difference between the two groups was non-significant