Table 3.
Change in functional, echocardiographic and hemodynamic parameters in non-White cohort with sequential triple combination therapy.
| Functional status | Change in mean (Δ)/%/category (%) | p-Value |
|---|---|---|
| REVEAL 2.0 risk category (Low-risk) | 0.001 | |
| Low-risk | +9 (75%) | |
| Intermediate-risk | −1 (0.08%) | |
| High-risk | −8 (47%) | |
| 6-min walk distance (meters) | +42.6 (15.7%) | 0.025 |
| WHO functional class | 0.003 | |
| I | +1 | |
| II | +9 (180%) | |
| III | −8 (23.5%) | |
| IV | −2 (100%) | |
| Diffusion capacity of carbon monoxide (%) | +7.76 (17.5%) | 0.021 |
| Brain natriuretic peptide (pg/dL) | −4.85 (10%) | 0.376 |
| Echocardiographic parameters | ||
| Tricuspid valve regurgitation velocity (m/s) | +0.56 (13.2%) | <0.001 |
| Tricuspid annulus planar systolic excursion (Low) | +8 (40%) | 0.013 |
| Right ventricular function (hypokinetic) | +9 (30%) | 0.012 |
| Right ventricular size | 0.016 | |
| Normal | +4 (80%) | |
| Mildly dilated | 0 (0%) | |
| Moderately dilated | −3 (17.6%) | |
| Severely dilated | −3 (30%) | |
| Hemodynamics | ||
| Systolic pulmonary artery pressure (mm Hg) | −12.9 (16%) | <0.001 |
| Diastolic pulmonary artery pressure (mm Hg) | −4.1 (13.2%) | 0.007 |
| Mean pulmonary artery pressure (mm Hg) | −6.9 (14.3%) | <0.001 |
| Pulmonary artery wedge pressure (mm Hg) | −1.0 (10%) | 0.487 |
| Pulmonary vascular resistance (woods unit) | −2.61 (30.3%) | <0.001 |
| Cardiac output (L/min) | +0.62 (14.2%) | 0.011 |
| Cardiac index (L/min/m2) | +0.43 (17.6%) | 0.003 |
| Mixed venous oxygen saturation (%) | +6.6 (10.5%) | <0.001 |