TABLE 1.
In vitro activity of a ketolide (HMR 3647) and a streptogramin (quinupristin-dalfopristin) against S. pneumoniae
| Resistance phenotype (no. of strains) | Antimicrobial agent | MIC (μg/ml)a
|
||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| Erys Clins (537) | HMR 3647 | ≤0.06–≤0.06 | ≤0.06 | ≤0.06 |
| Quin-Dalfb | ≤0.06–1.0 | 0.25 | 0.5 | |
| Erythromycin | ≤0.06–0.25 | ≤0.06 | ≤0.06 | |
| Clindamycin | ≤0.06–0.12 | ≤0.06 | ≤0.06 | |
| Eryr Clins (50) | HMR 3647 | ≤0.06–0.5 | 0.25 | 0.5 |
| Quin-Dalf | 0.12–4.0 | 0.5 | 0.5 | |
| Erythromycin | 1.0–8.0 | 4.0 | 8.0 | |
| Clindamycin | ≤0.06–0.25 | ≤0.06 | ≤0.06 | |
| Eryr Clinr (24) | HMR 3647 | ≤0.06–0.25 | ≤0.06 | ≤0.06 |
| Quin-Dalf | 0.25–1.0 | 0.5 | 0.5 | |
| Erythromycin | 1.0–>32 | >32 | >32 | |
| Clindamycin | 1.0–>32 | >32 | >32 | |
a
50% and 90%, MICs at which 50 and 90% of the isolates, respectively, are inhibited.
b
Quin-Dalf, quinupristin-dalfopristin (30:70 ratio).