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. 2023 Oct 5;12(1):2261326. doi: 10.1080/2162402X.2023.2261326

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — Defective host IL-17 signaling has variable impacts on tumor inflammation and angiogenesis protein expression depending on tumor type.

Mouse Angiogenesis Array Kit was used to assess the levels of tumor-related proteins in the lysates of B16.SIY melanomas and EL4.SIY lymphomas from WT, IL-17RA KO, and IL-17A/F DKO mice. (a) Array membranes after sample probing. Selected proteins of interest are annotated. (b) Heat maps showing the pixel intensity of the 27 proteins found in the lysates of either B16.SIY melanomas (left) or EL4.SIY lymphomas (right) developed in IL-17RA KO and IL-17A/F DKO mice compared to WT mice. (c) Bubble chart of significantly enriched KEGG pathways of the proteins that were over or under expressed in the B16.SIY melanomas and EL4.SIY lymphomas developed in IL-17RA KO or IL-17A/F DKO mice compared to WT mice. (d) Venn diagrams show differentially expressed proteins in B16.SIY versus EL4.SIY tumor lysates developed in IL-17RA KO compared to WT mice and IL-17A/F DKO mice compared to WT mice. P values are calculated with two-way ANOVA followed by Dunnett’s multiple comparison. *p < .05; **p < .01; ***p < .001; ****p < .0001.