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[Preprint]. 2023 Oct 4:2023.09.22.558628. [Version 2] doi: 10.1101/2023.09.22.558628

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Fig. 3. — Rectangular fields with one and two stars represent constructs/variants that have not been tested or for which IC₅₀ values were not quantifiable, respectively. Hours after infection / hours post infection (hpi). (A) Heat maps of IC₅₀ fold-changes of M^pro-On (bottom) and M^pro–Off (top) dose responses for nirmatrelvir and ensitrelvir. (B) Heat maps of IC₅₀ fold-changes for Omicron-M^pro-On (bottom) and Omicron-M^pro–Off (top) dose responses for nirmatrelvir and ensitrelvir. (C) Bar plot of TM₅₀ fold-changes vs the WT protease. The WT M^pro is coloured in black. (D) Bar plot of TM₅₀ fold-changes vs Omicron (orange) and Omicron/A206T (bordeaux) proteases. Variants are coloured in light orange and light bordeaux according to the parental protease from which they originated.