TABLE 1.
Antibiotic susceptibilities of a parent strain and final isolate after multiple serial passages through eperezolid
| Drug | MIC (μg/ml)
|
|
|---|---|---|
| S. aureus ATCC 29213a | S. aureus SA31593b | |
| Eperezolid | 2 | 32 |
| Lincomycin | 1 | 8 |
| Clindamycin | 0.12 | 0.5 |
| Erythromycin | 0.25 | 0.5 |
| Azithromycin | 1 | 1 |
| Chloramphenicol | 8 | 32 |
| Vernamycin | 8 | 8 |
| Tetracycline | 0.25 | 0.12 |
| Amikacin | 1 | 1 |
| Streptomycin | 8 | 8 |
| Gentamicin | 0.12 | 0.12 |
| Penicillin G | 0.5 | 0.5 |
| Ampicillin | 0.5 | 1 |
| Oxacillin | 0.12 | 0.12 |
| Cephalothin | 0.25 | 0.25 |
| Cefoxitin | 2 | 2 |
| Cefotaxime | 2 | 2 |
| Ceftazidime | 8 | 8 |
| Vancomycin | 0.5 | 1 |
| Ciprofloxacin | 0.25 | 0.5 |
a
Initial isolate (parental strain).
b
Final isolate (mutant derived from 20 serial passages on eperezolid).