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. 2023 Oct 5;15(2):2263210. doi: 10.1080/19490976.2023.2263210

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — Intestinal microbiota affects lipid peroxidation. Different antioxidant systems are effective in preventing lipid peroxidation, including the cysteine/GSH/GPX4 axis, the FSP1-CoQ10 axis, the GCH1-BH4 axis, the thioredoxin system, and the iNOS/NO• system. On the other hand, lipid autoxidation and lipoxygenase can pose dangerous risk factors for inducing lipid peroxidation. Gut microbes can regulate both the antioxidant systems and lipoxygenase, influencing ferroptosis. GSH, glutathione; GPX4, glutathione peroxidase 4; FSP1, ferroptosis suppressor protein 1; CoQ10, Ubiquinone; GCH1, GTP cyclohydrolase-1; BH4, Tetrahydrobiopterin; iNOS, inducible nitric oxide synthase.