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Across all species, evolved azithromycin MICs were significantly elevated compared to penicillin MICs in both (A) their final values (p < 0.0001), and (B) their fold-increase from ancestral MICs (p < 0.01). The (C) time for MICs to double was not significantly different between drugs (p > 0.05), as was the number of days to surpass the breakpoint value as defined by CLSI guidelines for Neisseria gonorrhoeae (P >0.05).
