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[Preprint]. 2023 Sep 29:2023.09.27.559828. [Version 1] doi: 10.1101/2023.09.27.559828

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Figure 2. — A. Diagram of experimental design. 1×10⁷ mCherry+ TKO mouse ovarian cancer cells were injected i.p. in C57BL/6 mice. Mice were randomized into treatment groups and treatment began when mCherry ROI fluorescence reaches 3.2×10⁸ PFU/cell (designated as day 0). Treatment was 1×10⁶ PFU of CARG-2020 or VLV-GFP given i.p. every 3 days for a total of 3 doses (arrows show days of treatment). Control no treatment mice received PBS (n=6 per group); B. Tumor growth was measured by mCherry ROI fluorescence (arrows show day of treatment); C. Representative images showing tumor regression only in CARG-2020 treated group; D. overall survival was defined as day mCherry ROI area reached 1×10⁹ PFU/cell and calculated using Kaplan Meier analysis.