Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2023 Sep 29:2023.09.27.559828. [Version 1] doi: 10.1101/2023.09.27.559828

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Figure 7. — top panel, Control no treatment ovarian tumors are “cold” and express/secrete IL-17 and PD-L1 leading to differentiation of pro-tumor M2 macrophages, which inhibit the expansion of cytotoxic CD8 T cells; bottom panel, CARG-2020, by expressing shRNA for PD-L1 and dominant negative for IL-17, in addition to promoting the secretion of IL-12, shifts the environment to a “hot” tumor and promotes the differentiation of antigen presenting cells and consequently expansion of cytotoxic CD8 T cells.