TABLE 2.
Results of checkerboard synergy testinga
| Group (n) | Result for combination with FIC index ofb:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Levofloxacin + cefpirome
|
Levofloxacin + ceftazidime
|
Levofloxacin + gentamicin
|
Levofloxacin + meropenem
|
|||||
| ≤0.5 | >0.5–4 | ≤0.5 | >0.5–4 | ≤0.5 | >0.5–4 | ≤0.5 | >0.5–4 | |
| Susceptible (30)c | 3 | 27 | 0 | 30 | 0 | 30 | 2 | 28 |
| Resistant | ||||||||
| Ceftazidime (26) | 3 | 23 | 3 | 23 | 1 | 25 | 2 | 24 |
| Gentamicin (21) | 0 | 21 | 0 | 21 | 0 | 21 | 0 | 21 |
| Meropenem (24) | 0 | 24 | 4 | 20 | 0 | 24 | 1 | 23 |
| Miscellaneous (23) | 3 | 20 | 1 | 22 | 0 | 23 | 2 | 21 |
a
No antagonistic FIC indices (>4) were found).
b
Results for FIC indices of ≤0.5 are synergistic, and those of >0.5 to 4.0 are additive or indifferent.
c
Susceptible to all compounds.