Table 1.
Putative target genes identified by co-localization analysis between AS-associated loci and eQTLs in NK cells.
| Lead GWAS Variant | P-value | GWAS | Putative Target Gene | Posterior probability of shared causal variant | Quantification method | eQTL study |
|---|---|---|---|---|---|---|
| rs27529 | 1.24E-40 | IGAS | ERAP1 | 0.99186 | microarray | Gilchrist et al. 2021 |
| rs6759298 | 2.07E-38 | IGAS | B3GNT2 | 0.97245 | RNA-seq | Schmiedel et al. 2018 |
| rs1128905 | 3.17E-10 | IGAS | ENTR1 | 0.8207 | microarray | Gilchrist et al. 2021 |
| rs1860545 | 8.66E-10 | IGAS | TNFRSF1A | 0.99673 | RNA-seq | Schmiedel et al. 2018 |
| rs11065898 | 5.41E-08 | IGAS | TMEM116 | 0.87563 | microarray | Gilchrist et al. 2021 |
| rs9619386 | 4.42E-07 | IGAS | UBE2L3 | 0.96397 | microarray | Gilchrist et al. 2021 |
| rs1250542 | 2.07E-06 | IGAS | ZMIZ1 | 0.87272 | microarray | Gilchrist et al. 2021 |
| rs1250542 | 2.07E-06 | IGAS | ZMIZ1 | 0.83268 | RNA-seq | Schmiedel et al. 2018 |
| rs952594 | 2.08E-06 | IGAS | APEH | 0.75689 | microarray | Gilchrist et al. 2021 |
| rs952594 | 2.08E-06 | IGAS | RBM6 | 0.91981 | RNA-seq | Schmiedel et al. 2018 |
| rs952594 | 2.08E-06 | IGAS | UBA7 | 0.94237 | microarray | Gilchrist et al. 2021 |
| rs952594 | 2.08E-06 | IGAS | UBA7 | 0.8851 | RNA-seq | Schmiedel et al. 2018 |
| rs6565217 | 2.82E-06 | IGAS | AC135050.3 | 0.91556 | RNA-seq | Schmiedel et al. 2018 |
| rs6565217 | 2.82E-06 | IGAS | STX4 | 0.94653 | RNA-seq | Schmiedel et al. 2018 |
| rs7191548 | 3.13E-06 | IGAS | EIF3CL | 0.7822 | microarray | Gilchrist et al. 2021 |
| rs7191548 | 3.13E-06 | IGAS | NPIPB8 | 0.97545 | microarray | Gilchrist et al. 2021 |
| rs7191548 | 3.13E-06 | IGAS | SGF29 | 0.85225 | microarray | Gilchrist et al. 2021 |
| rs7191548 | 3.13E-06 | IGAS | TUFM | 0.82246 | microarray | Gilchrist et al. 2021 |
| rs7191548 | 3.13E-06 | IGAS | TUFM | 0.95694 | RNA-seq | Schmiedel et al. 2018 |
| rs6583441 | 3.84E-06 | IGAS | IKZF1 | 0.96244 | RNA-seq | Schmiedel et al. 2018 |
| rs4690326 | 6.49E-06 | IGAS | DGKQ | 0.91883 | microarray | Gilchrist et al. 2021 |
| rs4690326 | 6.49E-06 | IGAS | DGKQ | 0.89989 | RNA-seq | Schmiedel et al. 2018 |
| rs4690326 | 6.49E-06 | IGAS | IDUA | 0.98988 | microarray | Gilchrist et al. 2021 |
| rs4690326 | 6.49E-06 | IGAS | SLC49A3 | 0.801 | RNA-seq | Schmiedel et al. 2018 |
| rs26481 | 9.17E-06 | UK Biobank | CAST | 0.95638 | microarray | Gilchrist et al. 2021 |
| rs26481 | 9.17E-06 | UK Biobank | ERAP1 | 0.95565 | microarray | Gilchrist et al. 2021 |
| rs2236167 | 3.57E-05 | IGAS | PPP2R3C | 0.9491 | microarray | Gilchrist et al. 2021 |